ADX71743

ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 can cross the blood-brain barrier (BBB) and possesses anxiolytic activity..


Cat. No.: EX-A11919	Purity: >98%

	Chemical structure of ADX71743

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	525	In-stock
50mg	825	In-stock
100mg	1225	In-stock
250mg	2125	In-stock
500mg	2925	In-stock

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CAS No.	1431641-29-0
Purity	>98%
Formula	C17H19NO2
Mol Weight	269.3383
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rebecca Klar, et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci. 2015 May 13;35(19):7600-15. [2]. Mikhail Kalinichev , et al. ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and in Vivo Characterization. Pharmacol Exp Ther. 2013 Mar;344(3):624-36. [3]. Kalinichev M, et al. ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
CoA	CoA of ADX71743

Smiles:	CCC1=NC2=C(O1)CC(CC2=O)C3=C(C=C(C=C3)C)C


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