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Product Information:

ADH-6 TFA

ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases.

Cat. No.: EX-A6890    Purity: >98%
Chemical
Chemical structure of ADH-6 TFA


For research only, Do not use for Human!

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Purity>98%
FormulaC31H37F3N8O11
Mol Weight754.6677
ColorOff-white to light yellow
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>4 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.

CoACoA of ADH-6 TFA

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