ACT-451840

ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial.


Cat. No.: EX-A8328F	Purity: >98%

	Chemical structure of ACT-451840

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	650	In-stock
50mg	865	In-stock
100mg	1265	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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Synonyms	Related 1984890-99-4
CAS No.	1314143-88-8
Purity	>98%
Formula	C47H54N6O3
Mol Weight	750.9701
Color	off-white to light yellow
State	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bruderer S, et al. First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity. Antimicrob Agents Chemother. 2015;59(2):935-942. [2]. Boss C, et al. Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action. ChemMedChem. 2016;11(18):1995-2014. [3]. Le Bihan A, et al. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. PLoS Med. 2016;13(10):e1002138. Published 2016 Oct 4.
CoA	CoA of ACT-451840

Smiles:	CC(N(CC1)CCN1C(C=C2)=CC=C2CN(C(C=CC3=CC=C(C=C3)C(C)(C)C)=O)[C@@H](CC4=CC=CC=C4)C(N5CCN(CC5)CC6=CC=C(C=C6)C#N)=O)=O


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