Acivicin hydrochloride

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.


Cat. No.: EX-A15679	Purity: >98%

	Chemical structure of Acivicin hydrochloride

For research only, Do not use for Human!

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Synonyms	AT-125 hydrochloride
Synonyms 2	U-42126 hydrochloride
CAS No.	161922-40-3
Purity	>98%
Formula	C5H8Cl2N2O3
Mol Weight	215.035
Color	Off-white to light yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, stored under nitrogen; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. [2]. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. [3]. Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60.
CoA	CoA of Acivicin hydrochloride

Smiles:	[H]Cl.ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1


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