ACI-19278

ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions.


Cat. No.: EX-A16271	Purity: >98%

	Chemical structure of ACI-19278

For research only, Do not use for Human!

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CAS No.	3033951-64-0
Purity	>98%
Formula	C20H17F2N5OS
Mol Weight	413.444
Color	Light yellow to yellow
State	solid
Solubility	soluable in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Vokali E, et al. Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology. Nat Commun. 2025 Oct 24;16(1):9358.
CoA	CoA of ACI-19278

Smiles:	FC1=C(C2=NC(CCN(C3=CN=CC=C3)C4=O)=C4S2)C=CC(N5CC[C@@H](F)C5)=N1


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