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Product Information:

AC220

Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM.

Cat. No.: EX-A335    Purity: >98%
Chemical
Chemical structure of AC220


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g387in_stock
5g1214in_stock
10g2077in_stock


SynonymsQuizartinib
CAS No.950769-58-1
Purity>98%
FormulaC29H32N6O4S
Mol Weight560.667
Colorwhite to off-white
Statesolid powder
SolubilitySoluble in DMSO/DMF
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zarrinkar PP, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood, 2009, 114(14), 2984-2992.

[2]. Puissant A, et al. SYK is a critical regulator of FLT3 in acute myeloid leukemia. Cancer Cell. 2014 Feb 10;25(2):226-42.

[3]. Sun X, et al. PROTACs: great opportunities for academia and industry. Signal Transduct Target Ther. 2019 Dec 24;4:64.

CoACoA of AC220
Smiles:CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C=C2)C2=CN3C(SC4=CC=C(OCCN5CCOCC5)C=C34)=N2)=NO1

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