Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .


Cat. No.: EX-A7456	Purity: >98%

	Chemical structure of Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

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Synonyms	N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
CAS No.	159439-02-8
Purity	>98%
Formula	C32H46N5O17P
Mol Weight	803.7047

Reference:	[1]. Gilmer, T et al. “Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.” The Journal of biological chemistry vol. 269,50 (1994): 31711-9. [2]. Pacofsky, G J et al. “Potent dipeptide inhibitors of the pp60c-src SH2 domain.” Journal of medicinal chemistry vol. 41,11 (1998): 1894-908. [3]. Park, See-Hyoung et al. “Design and characterization of non-phosphopeptide inhibitors for Src family SH2 domains.” Bioorganic & medicinal chemistry letters vol. 12,19 (2002): 2711-4.
CoA	CoA of Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH


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