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Product Information:

ABT-072

ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)

Cat. No.: EX-A13813    Purity: >98%
Chemical
Chemical structure of ABT-072


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg598In-stock
25mg1150
50mg1998


CAS No.1132936-00-5
Purity>98%
FormulaC24H27N3O5S
Mol Weight469.553
ColorOff-white to yellow
StateSolid
SolubilityDMSO : 80 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Lawitz E, et al. A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1. J Hepatol. 2013;59(1):18-23.

[2]. Shi Y, et al. Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method. J Pharm Sci. 2016;105(9):2886-2895.

[3]. Randolph JT, et al. Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability. J Med Chem. 2018;61(3):1153-1163.

CoACoA of ABT-072
Smiles:CS(=O)(NC1=CC=C(/C=C/C2=CC(N(C(N3)=O)C=CC3=O)=CC(C(C)(C)C)=C2OC)C=C1)=O

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