AB25583

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research.


Cat. No.: EX-A10039	Purity: >98%

	Chemical structure of AB25583

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	672	In-stock
50mg	988	In-stock
100mg	1382	In-stock
250mg	1960	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2565637-94-5
Purity	>98%
Formula	C22H17ClN4O3S
Mol Weight	452.913
Color	white to off-white
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15(1):7003.
CoA	CoA of AB25583

Smiles:	ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1


		Search