AB-452

AB-452 is a potent, small molecule inhibitor of noncanonical poly(A) polymerases PAPD5 and PAPD7 (PAPD5/7), inhibits PAPD5/7 enzymatic activities, reduces HBsAg in vitro (EC50=1.4/6.8 nM).


Cat. No.: EX-A8160	Purity: >98%

	Chemical structure of AB-452

For research only, Do not use for Human!

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CAS No.	2226178-35-2
Purity	>98%
Formula	C21H26N2O6
Mol Weight	402.4409
State	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Liu, Fei et al. “Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.” Journal of virology vol. 95,18 (2021): e0057421. doi:10.1128/JVI.00574-21
CoA	CoA of AB-452

Smiles:	N1C2=C(C[C@@H](C(C)C)N3C=C(C(O)=O)C(=O)C=C32)C=C(OCCCOC)C=1OC


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