AACOCF3

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease.


Cat. No.: EX-A12450	Purity: >98%

	Chemical structure of AACOCF3

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	490	In-stock
50mg	814	In-stock
100mg	1300	In-stock
250mg	2500	In-stock
500mg	4100	In-stock
1g	6600	In-stock

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CAS No.	149301-79-1
Purity	>98%
Formula	C21H31F3O
Mol Weight	356.4654
Color	Colorless to light yellow
State	Liquid
Shelf Life	>2 years if stored properly
Storage	Pure form Solution, -20°C, 2 years;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Riendeau D, et al. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J Biol Chem. 1994;269(22):15619-15624. [2]. Schanstra JP, et al. Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. JCI Insight. 2019;4(10):e125638. Published 2019 May 16. [3]. Loweth AC, et al. A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun. 1996;218(2):423-427.
CoA	CoA of AACOCF3

Smiles:	C(\CCCC(C(F)(F)F)=O)=C\C/C=C\C/C=C\C/C=C\CCCCC


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