A778317

A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid .


Cat. No.: EX-A14937	Purity: >98%

	Chemical structure of A778317

For research only, Do not use for Human!

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CAS No.	808756-64-1
Purity	>98%
Formula	C23H25N3O
Mol Weight	359.4641
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bianchi B R, et al. [3H] A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 323(1): 285-293.
CoA	CoA of A778317

Smiles:	O=C(N[C@@H]1CCC2=C1C=CC(C(C)(C)C)=C2)NC3=CC=CC4=C3C=CN=C4


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