A3AR agonist 1

A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM). A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC50 value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc.


Cat. No.: EX-A8259	Purity: >98%

	Chemical structure of A3AR agonist 1

For research only, Do not use for Human!

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Purity	>98%
Formula	C28H34N6O6
Mol Weight	550.6062
State	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences. CS Pharmacol. Transl. Sci. 2023, 6, 9, 1288–1305.
CoA	CoA of A3AR agonist 1

Smiles:	O=C(NC)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)N3C4=C(N=C3)C5=NC(OCC/C=C/CCOC6=C(OC)C=CC(CCN5)=C6)=N4


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