A-395

A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM.


Cat. No.: EX-A5003	Purity: >98%

	Chemical structure of A-395

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	1685	In-stock
1g	2485	In-stock
2g	get quote
5g	get quote
10g	get quote

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CAS No.	2089148-72-9
Purity	>98%
Formula	C26H35FN4O2S
Mol Weight	486.645
Color	white to off-white
State	White to yellow
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13(4):389-395.
CoA	CoA of A-395

Smiles:	CN(C)[C@H]1CN(C[C@@H]1C2=CC=C(C=C2)N3CCN(CC3)S(=O)(=O)C)C4CCC5=C4C(=CC=C5)F


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