YJ1206

YJ1206 is an orally active, selective CDK12/CDK13 PROTAC degrader with an IC50 of 12.55 nM for in VCaP cells. YJ1206 increases DNA damage, induces apoptosis, and promotes tumor regression in orthotopic WA74 patient-derived xenograft (PDX) mice models of resistant prostate cancer. YJ1206 suppresses tumor growth in vivo in conjunction with AKT pathway inhibitors.


Cat. No.: EX-A12082	Purity:

	Chemical structure of YJ1206

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	700	In-stock
250mg	1100	In-stock
500mg	1700	In-stock
1g	2600	In-stock
3g	get quote	Inquire
5g	get quote	Inquire

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CAS No.	3053716-98-3
Formula	C49H52FN11O5
Mol Weight	894.0063
Appearance	Light yellow to yellow solid
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yu Chang, et al. Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition. Cell Rep Med. 2024 Oct 15;5(10):101752.
CoA	CoA of YJ1206

Smiles:	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC4)N5CCN(CC5)C6=CC=C(N(C(NCC7=CC=CC=C7)=O)[C@@H]8CC[C@@H](NC9=NC%10=C(C=N9)C=CC=C%10)CC8)C=N6


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