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Product Information:

TH-Z835

TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM. TH-Z835 binds to both GDP-bound and GMPPNP-bound KRAS G12D. TH-Z835 displayed anti-tumor effects in xenograft pancreatic tumor models.

Cat. No.: EX-A6376    Purity: >98%
Chemical
Chemical structure of TH-Z835


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg29505-6 weeks
100mg42505-6 weeks
200mg59505-6 weeks


CAS No.2766209-50-9
Purity>98%
FormulaC30H38N6O
Mol Weight498.6623
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mao, Z., Xiao, H., Shen, P. et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov 8, 5 (2022).

CoACoA of TH-Z835

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