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Product Information:

TAK-243

TAK-243 is a selective ubiquitin activating enzyme, UAE (UBA1) inhibitor, blocks ubiquitin conjugation, disrupting monoubiquitin signaling and global protein ubiquitination.

Cat. No.: EX-A5569    Purity: >98%
Chemical
Chemical structure of TAK-243


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg580In-stock
250mg950In-stock
500mg1450In-stock
1g1950In-stock


SynonymsMLN-7243
CAS No.1450833-55-2
Purity>98%
FormulaC19H20F3N5O5S2
Mol Weight519.518
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Hyer ML, et al. A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment. Nat Med. 2018 Feb;24(2):186-193.

[2]. Best SR, et al. TAK-243, a small molecule inhibitor of ubiquitin-activating enzyme (UAE), induces ER stress and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Blood 2017 130:1533.

[3]. Samir H. Barghout, et al. TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML). Blood 2017, 130:814.
CoACoA of TAK-243

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