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Product Information:

Spliceostatin A

Spliceostatin A is a methylated derivative of FR-901464 that inhibits pre-mRNA splicing.

Cat. No.: EX-A6219    Purity: >98%
Chemical
Chemical structure of Spliceostatin A


For research only, Do not use for Human!

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CAS No.391611-36-2
Purity>98%
FormulaC28H43NO8
Mol Weight521.6429
AppearanceWhite to off-white solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -60℃ 2 years; In solvent -80℃ 1 month;
ShippingDry ice
 
 
Reference:  

[1]. Kaida D, et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol. 2007 Sep;3(9):576-83.

[2]. Roybal GA, et al. Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation. Nucleic Acids Res. 2010 Oct;38(19):6664-72.

[3]. Larrayoz M, et al. The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1. Leukemia. 2016 Feb;30(2):351-60.

CoACoA of Spliceostatin A

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