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Product Information:

Seco-DUBA

Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).

Cat. No.: EX-A6014    Purity: >95%
Chemical
Chemical structure of Seco-DUBA


For research only, Do not use for Human!

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CAS No.1227961-59-2
Purity>95%
FormulaC29H23ClN4O4
Mol Weight526.97
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
Storage -20℃, stored under nitrogen In solvent : -80℃, 6 months; -20℃, 1 month (stored under nitrogen)
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015;12(6):1813-1835.

CoACoA of Seco-DUBA

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