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Product Information:

Rezatapopt

Rezatapopt (PC14586) is an antineoplastic agent, used to inhibit solid tumor with p53 mutation.

Cat. No.: EX-A8780    Purity: >98%
Chemical
Chemical structure of Rezatapopt


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg728In-stock
250mg1332In-stock
500mg2100In-stock
1g3480In-stock
2gget quoteIn-stock
5gget quoteIn-stock


SynonymsPC14586
Synonyms 2PC-14586
CAS No.2636846-41-6
Purity>98%
FormulaC28H31F4N5O2
Mol Weight545.5717
AppearanceLight yellow to yellow solid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Li Sujing, et al. Heteroarylalkyne compounds for targeting mutant of p53 and their preparation. World Intellectual Property Organization, WO2023016434 A1. 2023-02-16.

[2]. Vu BT, et al. Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. ACS Med Chem Lett. 2024 Nov 4;16(1):34-39.

[3]. Spiegelberg D, et al. Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools. Sci Rep. 2025 Jan 6;15(1):1000.

[4]. Schram A M, et al. 691TiP PYNNACLE phase II trial of rezatapopt (PC14586) in solid tumors with a TP53 Y220C mutation[J]. Annals of oncology, 2024, 35: S535-S536.

Data SheetData sheet of Rezatapopt
CoACoA of Rezatapopt
SDSSDS of Rezatapopt
Smiles:FC(F)(F)CN1C2=CC=CC(N[C@H]3[C@H](CN(CC3)C)F)=C2C=C1C#CCNC4=C(C=C(C=C4)C(NC)=O)OC

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