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Retro 2

Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].

Cat. No.: EX-A14811    Purity: >98%
Chemical
Chemical structure of Retro 2


For research only, Do not use for Human!

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CAS No.1201652-50-7
Purity>98%
FormulaC19H16N2OS
Mol Weight320.408
 
 
Reference:  

[1]. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42.

[2]. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.

[3]. Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163.

CoACoA of Retro 2
Smiles:CC1=CC=C(S1)C=NC2=CC=CC=C2C(=O)NC3=CC=CC=C3

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