NecroX-7

NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) researc.


Cat. No.: EX-A7504	Purity: >98%

	Chemical structure of NecroX-7

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	760	In-stock
100mg	1160	In-stock
200mg	1860	In-stock

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CAS No.	1120332-55-9
Purity	>98%
Formula	C24H29N3O3S
Mol Weight	439.57
Appearance	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Im KI, et al. The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release. J Immunol. 2015 Jun 1;194(11):5223-32. [2]. Im, Keon-Il et al. “Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis.” Mucosal immunology vol. 12,5 (2019): 1070-1081. [3]. Hwang, In-Chang et al. “Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia-Reperfusion Injury.” Hypertension (Dallas, Tex. : 1979) vol. 71,6 (2018): 1143-1155.
CoA	CoA of NecroX-7


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