NVP-BSK 805

NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.


Cat. No.: EX-A286	Purity: >98%

	Chemical structure of NVP-BSK 805

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	850	In-stock
500mg	1450	In-stock
1g	2485	In-stock
2g	3450	In-stock
5g	7850	In-stock

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Synonyms	NVP-BSK805
CAS No.	1092499-93-8
Purity	>98%
Formula	C27H28F2N6O
Mol Weight	490.5476
Appearance	Off-white to yellow solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. [2]. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182.
CoA	CoA of NVP-BSK 805

Smiles:	FC1=CC(=CC(F)=C1CN1CCOCC1)C1=C2N=C(C=NC2=CC=C1)C1=CN(N=C1)C1CCNCC1


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