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Product Information:

NGI-235

NGI-235 is a selective OST-A inhibitor that inhibits NF-κB inflammatory signaling by blocking TLR4 glycosylation .

Cat. No.: EX-A15832    Purity: >98%
Chemical
Chemical structure of NGI-235


For research only, Do not use for Human!

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CAS No.2763063-40-5
Purity>98%
FormulaC25H30N4O3S2
Mol Weight498.661
AppearanceLight yellow to yellow solid
Solubilitysoluble in DMSO
Storage4℃, sealed storage, away from moisture, 2 years
 
 
Reference:  

[1]. Lampson BL, et al. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024 Apr 25;187(9):2209-2223.e16.

CoACoA of NGI-235
Smiles:O=C(C1=CC(S(=O)(N(CC2=CC=CC=C2)C)=O)=CC=C1N(CC3CC3)C)NC4=NC=C(CC)S4

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