MTDIA HCl

Methylthio-DADMe-immucillin-A (MT-DADMe-ImmA) is an 86-pm inhibitor of human 5-methylthioadenosine phosphorylase (MTAP). Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibited MTAP, increased cellular MTA concentrations, decreased polyamines, and induced apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines.The selective action of MT-DADMe-ImmA on head and neck squamous cell carcinoma cells suggests potential as an agent for treatment of cancers sensitive to reduced CpG island methylation.


Cat. No.: EX-A5565	Purity: >98%

	Chemical structure of MTDIA HCl

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	385	In-stock
25mg	500	In-stock
50mg	650	In-stock
100mg	900	In-stock
250mg	1750	In-stock
1g	3900	In-stock

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Synonyms	MT-DADMe-ImmA
CAS No.	1399840-35-7
Purity	>98%
Formula	C13H20ClN5OS
Mol Weight	329.849
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89. PubMed PMID: 16000004. [2]. Tang B, Kadariya Y, Chen Y, Slifker M, Kruger WD. Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3 (Bethesda). 2014 Nov 11;5(1):35-44. doi: 10.1534/g3.114.014555. PubMed PMID: 25387827; PubMed Central PMCID: PMC4291467. [3]. Basu I, Cordovano G, Das I, Belbin TJ, Guha C, Schramm VL. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86. Epub 2007 Jun 4. PubMed PMID: 17548352.
CoA	CoA of MTDIA HCl


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