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Product Information:

LX9211

LX9211 (BMS-986176) is a highly selective, CNS penetrant, potent AAK1 inhibitor from a novel class of bi(hetero)aryl ethers.

Cat. No.: EX-A5979    Purity: >98%
Chemical
Chemical structure of LX9211


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg800In-stock
100mg1100In-stock
250mg1900In-stock
500mg2900In-stock
1g3900In-stock
5gget quoteIn-stock


SynonymsBMS-986176
CAS No.1815613-42-3
Purity>98%
FormulaC19H23F4N3O
Mol Weight385.399
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Luo G, Chen L, Kostich WA, et al. Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022;65(6):4457-4480. doi:10.1021/acs.jmedchem.1c02131.

[2]. Bundrant L, Hunt TL, Banks P, et al. Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants. Clin Ther. 2021;43(6):1029-1050. doi:10.1016/j.clinthera.2021.04.014

CoACoA of LX9211

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