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Product Information:

JHU083

JHU-083 is a selective glutaminase antagonist.

Cat. No.: EX-A3389    Purity: >98%
Chemical
Chemical structure of JHU083


For research only, Do not use for Human!

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SynonymsJHU-083
CAS No.1998725-11-3
Purity>98%
FormulaC14H24N4O4
Mol Weight312.3648
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
Storagestored under nitrogen, -20℃, protect from light
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694.

[2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
CoACoA of JHU083
Smiles:O=C(OCC)[C@H](CCC(C=[N+]=[N-])=O)NC([C@H](CC(C)C)N)=O

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