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Product Information:

JB170

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.

Cat. No.: EX-A7164    Purity: >98%
Chemical
Chemical structure of JB170


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg1085Inquire
100mg2800Inquire
250mg3800Inquire
1g5960Inquire


CAS No.2705844-82-0
Purity>98%
FormulaC48H44ClFN8O11
Mol Weight963.361
Appearancesolid powder
SolubilityDMSO >50 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Adhikari B, et al. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nat Chem Biol. 2020;16(11):1179-1188.

CoACoA of JB170

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