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Product Information:

JAB-3312

JAB-3312 is a potent oral allosteric SHP2 inhibitor. JAB-3312 exhibited a SHP2 binding Kd of 0.37 nM, SHP2 enzymatic IC50 of 1.9 nM, KYSE-520 antiproliferative IC50 of 7.4 nM and p-ERK inhibitory IC50 of 0.23 nM.

Cat. No.: EX-A9767    Purity: >98%
Chemical
Chemical structure of JAB-3312


For research only, Do not use for Human!

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SynonymsJAB3312
CAS No.2245082-05-5
Purity>98%
FormulaC21H22ClN7S
Mol Weight439.964
 
 
Reference:  

[1]. Ma, Cunbo et al. “Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.” Journal of medicinal chemistry vol. 67,16 (2024): 13534-13549. doi:10.1021/acs.jmedchem.4c00360

CoACoA of JAB-3312

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