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Product Information:

ISRIB

ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB racemate (548470-11-7) please refer to EX-A298.

Cat. No.: EX-A298    Purity: >98%
Chemical
Chemical structure of ISRIB


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg385In-stock
500mg485In-stock
1g650In-stock
5g1850In-stock


SynonymsISRIB (trans-isomer)
Synonyms 2548470-11-7
CAS No.1597403-47-8
Purity>98%
FormulaC22H24Cl2N2O4
Mol Weight451.343
Appearancewhite to off-white powder
SolubilityDMSO >20mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498.

[2]. Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.

CoACoA of ISRIB
Smiles:ClC1=CC=C(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COC2=CC=C(Cl)C=C2)C=C1

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