GSK1362

GSK1362 (GSK3201362) is an antagonist of NR1D1, and the interaction with the O-methyl ethanolamine side chain and Lys473 through hydrogen bonds is essential for its effects.. GSK1362 inhibits LPS-induced production of several inflammatory cytokines by alveolar macrophages, especially Il-6 gene expression [119].


Cat. No.: EX-A12041	Purity: >98%

	Chemical structure of GSK1362

For research only, Do not use for Human!

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Synonyms	GSK3201362
CAS No.	2986733-57-5
Purity	>98%
Formula	C21H21ClN4O2
Mol Weight	396.87
Appearance	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder 4℃,protect from light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang-Sun, Zi-Yin et al. “Targeting NR1D1 in organ injury: challenges and prospects.” Military Medical Research vol. 10,1 62. 11 Dec. 2023, doi:10.1186/s40779-023-00495-3
CoA	CoA of GSK1362

Smiles:	N#CC=1N=C(OC1NCCOC)C=2C=CC(=CC2)N(C)CC3=CC=C(Cl)C=C3


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