GS-5718

Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research.


Cat. No.: EX-A9060	Purity: >98%

	Chemical structure of GS-5718

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	2900	In-stock
250mg	3800	In-stock
500mg	4880	In-stock
1g	6680	In-stock

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Synonyms	Edecesertib
Synonyms 2	GS5718
CAS No.	2408839-73-4
Purity	>98%
Formula	C22H22FN7O2
Mol Weight	435.4542
Appearance	Light yellow to yellow solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture and light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Roedder S, et, al. Phase 1 Study Results of GS-5718, an Oral IRAK4-Inhibitor: Pharmacodynamics of Single and Multiple Doses of GS-5718 in Healthy Subjects. 2021 Nov 6. [2]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical [3]. Feng Y, et al. Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer[J]. Acta Pharmaceutica Sinica B, 2024. [4]. Kurochkina Y, et al. POS0673 TOLEROGENIC DENDRITIC CELLS IN RHEUMATOID ARTHRITIS PATIENTS: NEWS AND PROMISES[J]. 2021. [5]. Kalliolias GD, et al. Targeting TLR Signaling Cascades in Systemic Lupus Erythematosus and Rheumatoid Arthritis: An Update. Biomedicines. 2024 Jan 9;12(1):138. [6]. Ammann S, et al., Pyrrolo[1,2-b] pyridazine derivatives. WO2020014468A1.
CoA	CoA of GS-5718


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