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Product Information:

GNE-8505

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK) .

Cat. No.: EX-A8568    Purity: >98%
Chemical
Chemical structure of GNE-8505


For research only, Do not use for Human!

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CAS No.1620573-48-9
Purity>98%
FormulaC21H24F3N5O
Mol Weight419.4434
AppearanceWhite to off-white solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394.

CoACoA of GNE-8505
Smiles:FC(F)(F)C1=CC(C2=NN(C([C@@H]3[C@]4([H])[C@@]3([H])CN(C5COC5)C4)=C2)CC6CC6)=CN=C1N

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