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Product Information:

GNE-7915

GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.

Cat. No.: EX-A1001    Purity: >98%
GNE-7915
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg300In-stock
500mg400In-stock
1g650In-stock
2g1100In-stock
5g2400In-stock
10g3840In-stock


CAS No.1351761-44-8
Purity>98%
FormulaC19H21F4N5O3
Mol Weight443.3954
AppearanceOff-white to light yellow solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23(13):3690-6.

[2]. Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.

CoACoA of GNE-7915
Smiles:CCNC1=NC(NC2=C(OC)C=C(C(=O)N3CCOCC3)C(F)=C2)=NC=C1C(F)(F)F

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