GFH009

JSH-009 (JSH-150) is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. JSH-009 demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML).


Cat. No.: EX-A9179	Purity: >98%

	Chemical structure of GFH009

For research only, Do not use for Human!

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Synonyms	JSH-150
Synonyms 2	Tambiciclib
CAS No.	2247481-08-7
Purity	>98%
Formula	C25H35ClN6O2S
Mol Weight	519.102
Appearance	White to yellow solid
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang L, et al. Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models. Invest New Drugs. 2020 Oct;38(5):1272-1281. [1]. Wang, Beilei et al. “Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.” European journal of medicinal chemistry vol. 158 (2018): 896-916. doi:10.1016/j.ejmech.2018.09.025
CoA	CoA of GFH009


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