Ensifentrine

Ensifentrine (RPL554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively.


Cat. No.: EX-A6633	Purity: >98%

	Chemical structure of Ensifentrine

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	485	In-stock
100mg	685	In-stock
200mg	1085	In-stock
500mg	1685	In-stock
1g	2485	In-stock
5g	6600	In-stock

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Synonyms	RPL554
CAS No.	1884461-72-6
Purity	>98%
Formula	C26H31N5O4
Mol Weight	477.5554
Appearance	light-yellow solid powder
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Victoria Boswell-Smith, et al. The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one]. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8. [2]. Henrik Watz, et al. Symptom Improvement Following Treatment with the Inhaled Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine in Patients with Moderate to Severe COPD - A Detailed Analysis. Int J Chron Obstruct Pulmon Dis. 2020 Sep 16;15:2199-2206.
CoA	CoA of Ensifentrine


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