EMD 386088 hydrochloride

EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3][4].


Cat. No.: EX-A15423	Purity: >98%

	Chemical structure of EMD 386088 hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	472	in-stock
250mg	756	in-stock
500mg	1112	in-stock
1g	1445	in-stock

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CAS No.	1171123-46-8
Purity	>98%
Formula	C14H16Cl2N2
Mol Weight	283.196

Reference:	[1]. Yun HM, et al. 5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events. Toxicol In Vitro. 2011 Dec;25(8):2035-40. [2]. Meneses A, et al. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195(1):112-9. [3]. Amodeo DA, et al. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behav Brain Res. 2018 Sep 3;349:8-15. [4]. Mattsson C, et al. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4.
CoA	CoA of EMD 386088 hydrochloride

Smiles:	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl


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