Product Information:

Cicaprost

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM.


Cat. No.: EX-A11442	Purity: >98%

	Chemical structure of Cicaprost

For research only, Do not use for Human!

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Synonyms	ZK 96480
CAS No.	94079-80-8
Purity	>98%
Formula	C22H30O5
Mol Weight	374.4706

Reference:	[1]. Nicole Ferko, et al. NO synergism with cicaprost in the canine pulmonary artery. BioPharm Journal ONLINE 2:2 (1998). [2]. Lucie H Clapp, et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol. 2002 Feb;26(2):194-201. [3]. Kevin B S Chow, et al. Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent. Eur J Pharmacol. 2003 Aug 1;474(1):7-13. [4]. T Murata, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 1997 Aug 14;388(6643):678-82.
CoA	CoA of Cicaprost

Smiles:	CCC#CC[C@H](C)[C@H](O)C#C[C@@H]1[C@]2([H])[C@@](C[C@H]1O)([H])C/C(C2)=C\COCC(O)=O


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