background


Product Information:

Calicheamicin gamma(1)

Calicheamicin, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor.

Cat. No.: EX-A2429    Purity: >98%
Chemical
Chemical structure of Calicheamicin gamma(1)


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg1000In-stock
50mg1500In-stock
100mg2200In-stock
250mg3200In-stock
500mg4500In-stock
1gGet quoteIn-stock


SynonymsCalicheamicin γ1
Synonyms 2Calicheamicin
CAS No.108212-75-5
Purity>98%
FormulaC55H74IN3O21S4
Mol Weight1368.348
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Damelin M, et al. Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions. Clin Cancer Res. 2015 Sep 15;21(18):4165-73

[2]. de Vries JF, et al. The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells. Leukemia. 2012 Feb;26(2):255-64

[3]. Takeshita A, et al. CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. Leukemia. 2009 Jul;23(7):1329-36.

CoACoA of Calicheamicin gamma(1)
Smiles:[H][C@@]1(C[C@H](OC)[C@H](CO1)NCC)O[C@@H]1[C@@H](O)[C@H](NO[C@H]2C[C@H](O)[C@H](SC(=O)C3=C(OC)C(OC)=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](OC)[C@H]4O)C(I)=C3C)[C@@H](C)O2)[C@@H](C)O[C@@]1([H])O[C@H]1C#C\C=C/C#C[C@]2(O)CC(=O)C(NC(=O)OC)=C1/C2=C/CSSSC

KEYWORDS: buy Calicheamicin gamma(1) | Calicheamicin gamma(1) supplier | purchase | cost | manufacturer | order | distributor | buy 108212-75-5 | 108212-75-5 supplier