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Product Information:

CFI-402257

CFI-402257 is a potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM.

Cat. No.: EX-A2577    Purity: >98%
CFI-402257
For research only, Do not use for Human!

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25mg800In-stock
50mg1200In-stock
100mg2100In-stock
200mg3300In-stock
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CAS No.1610759-22-2
Purity>98%
FormulaC28H30N6O3
Mol Weight498.5762
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Mason JM, et al. Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.

[2]. Liu Y, et al. Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent. ACS Med Chem Lett. 2016 May 6;7(7):671-5.
CoACoA of CFI-402257
Smiles:CC1=CC(=CC=C1C(=O)NC1CC1)C1=C2N=C(OC3=CN=CC=C3)C=C(NC[C@H]3C[C@@](C)(O)C3)N2N=C1

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