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Product Information:

CDK-IN-9

CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .

Cat. No.: EX-A10025    Purity: >98%
Chemical
Chemical structure of CDK-IN-9


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg900In-stock
50mg1400In-stock
100mgget quoteIn-stock
500mgget quote


CAS No.3031561-92-6
Purity>98%
FormulaC21H24N8S
Mol Weight420.534
Appearancesolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Jorda R, et al. 3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J Med Chem. 2022 Jul 14;65(13):8881-8896.

CoACoA of CDK-IN-9
Smiles:NCCSC1=NC2=C(NN=C2C(NCC3=CC=C(C=C3)N4C=CC=N4)=N1)C5CCC5

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