BBO-8520

BBO-8520 is a direct small molecule covalent inhibitor targeting KRAS^G12C. BBO-8520 has both KRASG12C (OFF) inhibitor properties and blocks KRAS^G12C(ON).


Cat. No.: EX-A8854	Purity: >98%

	Chemical structure of BBO-8520

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	3900	In-stock
250mg	5642	In-stock
500mg	8642	In-stock
1g	get quote	In-stock

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CAS No.	2893809-51-1
Purity	>98%
Formula	C35H33F6N7O2S
Mol Weight	729.738
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Maciag A E, et al. Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding[J]. Cancer Research, 2024, 84(7_Supplement): ND07-ND07. [2]. Caughey B A, Strickler J H. Targeting KRAS-Mutated Gastrointestinal Malignancies with Small-Molecule Inhibitors: A New Generation of Breakthrough Therapies[J]. Drugs, 2024, 84(1): 27-44.
CoA	CoA of BBO-8520

Smiles:	FC1=[C@](C(C(F)(F)F)=CC2=C(N=C(N=C21)OC[C@@]34CCCN3C[C@@H](C4)F)N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C)[C@]6=CC=C(F)C7=C6C(C#N)=C(N)S7


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