Angstrom6

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.


Cat. No.: EX-A7460	Purity: >98%

	Chemical structure of Angstrom6

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	450	In-stock
50mg	750	In-stock
100mg	1250	In-stock

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Synonyms	A6 peptide
Synonyms 2	CD44 modulating peptide SPL-108
CAS No.	220334-14-5
Purity	>98%
Formula	C39H62N10O15
Mol Weight	910.9676
Appearance	solid powder
Solubility	Soluble in DMSO,water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 20 [2]. Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. [3]. Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082.
CoA	CoA of Angstrom6


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