AZ194

AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects.


Cat. No.: EX-A5685	Purity: >98%

	Chemical structure of AZ194

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	750	In-stock
200mg	1050	In-stock
500mg	1650	In-stock
1g	3000	In-stock

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Synonyms	CRMP2-Ubc9-NaV1.7 inhibitor 194
CAS No.	2241651-99-8
Purity	>98%
Formula	C34H31F2N3O3
Mol Weight	567.625
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cai S, et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Sci Transl Med. 2021;13(619):eabh1314. [2]. Khanna, May, et al. Preparation of substituted piperidinyl-benzoimidazoles as small molecule antagonists of SUMO related modification of CRMP2 and uses thereof. WO2018144900 A1.
CoA	CoA of AZ194


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