ABCI1

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.


Cat. No.: EX-A5065	Purity: >98%

	Chemical structure of ABCI1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	1100	In-stock
500mg	1550	In-stock
1g	2400	In-stock
2g	3900	In-stock
5g	9800	In-stock

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CAS No.	2375564-55-7
Purity	>98%
Formula	C49H58FN9O7S
Mol Weight	936.104
Appearance	Solid powder
Solubility	Soluble in DMSO, methanol
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
CoA	CoA of ABCI1

Smiles:	CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2


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