8-Azanebularine

8-Azanebularine inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction.


Cat. No.: EX-A7845Y	Purity: >98%

	Chemical structure of 8-Azanebularine

For research only, Do not use for Human!

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CAS No.	38874-46-3
Purity	>98%
Formula	C9H11N5O4
Mol Weight	253.2147
Color	White to yellow
State	solid powder
Solubility	DMSO : 50 mg/mL H2O : 5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126(36):11213-11219.
CoA	CoA of 8-Azanebularine

Smiles:	O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2


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