740 Y-P

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .


Cat. No.: EX-A7449	Purity: >98%

	Chemical structure of 740 Y-P

For research only, Do not use for Human!

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CAS No.	1236188-16-1
Purity	>98%
Formula	C141H222N43O39PS3
Mol Weight	3270.705
Color	White to off-white
State	solid powder
Solubility	H2O : 4.8 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. [2].Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater. 2018 Nov;81:278-292. [3].Zhiqing Sun, et al. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease. J Alzheimers Dis. 2020;76(4):1513-1526.
CoA	CoA of 740 Y-P


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