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Product Information:

7-Hydroxymethyl-10,11-MDCPT

7-Hydroxymethyl-10,11-MDCPT is a hydrophilic camptothecin analog. 7-Hydroxymethyl-10,11-MDCPT is a payload that can be used for ADC synthesis

Cat. No.: EX-A11838    Purity: >98%
Chemical
Chemical structure of 7-Hydroxymethyl-10,11-MDCPT


For research only, Do not use for Human!

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CAS No.428816-69-7
Purity>98%
FormulaC22H18N2O7
Mol Weight422.3875
ColorOff-white to yellow
StateSolid
SolubilityDMSO : 4 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Cai JQ, Human anti-human HER3 antibodies and ADCs or drug conjugates for therapy, prevention and diagnosis of cancer or infection. 2023. WO2023143263

[2]. Wadkins RM, et al. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004;64(18):6679-6683.

CoACoA of 7-Hydroxymethyl-10,11-MDCPT
Smiles:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCO6)CO)O

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