5LUB

δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .


Cat. No.: EX-A15173	Purity: >98%

	Chemical structure of 5LUB

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	562	In-stock
1g	692	In-stock
5g	get quote	In-stock

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Synonyms	δ-Secretase inhibitor 11
CAS No.	842964-18-5
Purity	>98%
Formula	C10H12N4O2
Mol Weight	220.2279
Color	Brown to dark brown
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	4°C, protect from light; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740.
CoA	CoA of 5LUB

Smiles:	NC1=CC=C(N2CCOCC2)C3=NON=C31


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