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Product Information:

5A2-SC8

5A2-SC8 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. 5A2-SC8 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

Cat. No.: EX-A7328    Purity: >95%
Chemical
Chemical structure of 5A2-SC8


For research only, Do not use for Human!

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CAS No.1857341-90-2
Purity>95%
FormulaC93H173N5O20S5
Mol Weight1841.715
AppearanceLiquid
Shelf Life>2 years if stored properly
StoragePure -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhou, Kejin et al. “Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.” Proceedings of the National Academy of Sciences of the United States of America vol. 113,3 (2016): 520-5. doi:10.1073/pnas.1520756113

[2]. Johnson, Lindsay T et al. “Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.” Molecular pharmaceutics vol. 19,11 (2022): 3973-3986. doi:10.1021/acs.molpharmaceut.2c00442

[3]. Johnson, et al. The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes. Diss. 2022.

CoACoA of 5A2-SC8

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